http://rosenfeldlab.ucsd.edu/
We are investigating the molecular strategies used to generate genome-wide, integrated transcriptional responses to the vast signaling network that regulates development and homeostasis. We are using genetic, biochemical and biological approaches to define the strategies used by the human body to specify modifications to development and differentiation of cells when genes are expressed. Our work has revealed unexpected gene-specific strategies that link regulated gene responses to other cellular response programs, including DNA damage and DNA repair. Defining these strategies has suggested new approaches to diseases, including growth defects, diabetes, arteriosclerosis, and several prevalent forms of cancer.
Regulatory Strategies in Development and Function of the Neuroendocrine System
Molecular Mechanisms of Regulated Gene Transcription
Neural Stem Cells--Corepressor Strategies in Neuronal Development
Macrophage: Cancer Cell Interactions in Breast and Prostate Cancers
Sensors and Signals--coactivator and corepressor complexes in genome-wide patterns of gene expression
Neurodegenerative Diseases
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